The Crosstalk between MicroRNA-196a and Annexin-A1: A Potential Mechanism for Oral Squamous Cell Carcinoma Progression

Oral squamous cell carcinoma is the most common malignancy of oral neoplasm, comprising for more than 90 % all malignancies, as well approximately 38 head and neck tumors. So, it great significance to find potential therapeutic target disorder. The messenger ribonucleic acid micro expression profiling was performed patients; acid-messenger regulatory network established; functions were further explored in Cal27 adenosquamous line. Compared with normal mucosa, patients demonstrated 192 differentially expressed genes (66 up-regulated 126 downregulated) 23 acids (4 19 downregulated), among which acid-196a annexin-A1 significant expressed. a direct supported by bioinformatics luciferase analysis. antagomiR-196a technique utilized silence activity acid-196a. By this, shown modulate cellular migration, invasion colony formation through annexin-A1. At same time, closely associated protein kinase B mitogen-activated signaling pathways. This integrated study hypothesized dependent axis provided beneficial reference future clinical study.